Validation of SeptiCyte RAPID to Discriminate Sepsis from Non-Infectious Systemic Inflammation

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From the introduction Sepsis is an important and expensive global health problem with high morbidity and mortality. According to the World Health Organization, more than 11 million people die from sepsis worldwide annually—more than the deaths caused by all cancers combined and comprising almost 20% of all deaths annually. Sepsis is the leading cause of…

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A Fully Integrated Diagnostic Test to Discriminate Sepsis from Infection-Negative Systemic Inflammation

Sepsis is a serious medical condition that manifests with a dysregulated immune response to an infection in the bloodstream, and is a major cause of morbidity and mortality worldwide. Many non-infectious conditions can lead to a state of hyper-inflammation known as the systemic inflammatory response syndrome (SIRS), which clinically can look very similar to sepsis.…

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Blood transcriptomic discrimination of bacterial and viral infections in the emergency department: a multi-cohort observational validation study

Abstract Background There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions. Methods We used computational machine learning to derive a rule-out blood transcriptomic signature of bacterial infection (SeptiCyte™ TRIAGE) from eight published case-control studies. We then validated this signature by…

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